A first-of-its-kind brain activity experiment in the International Space Station

Beginning April 2nd and running through April 8th, brain.space will conduct a first-of-its-kind brain activity experiment in the International Space Station using its proprietary EEG-enabled headset, as operated by the astronauts of Axiom-1 (AX-1).
EEG headset

The experiment — performed in cooperation with the Rakia Mission — is designed and executed with the support of the Ben Gurion University’s Department of Cognitive and Brain Sciences.

The headset and all related hardware are planned to be soft-stowed and launched with the AX-1 ascent vehicle — a SpaceX Dragon rocket.

During its operation in the US Lab of the International Space Station (ISS), the brain.space headset will record and analyze neurological activity of crewmembers in order to determine whether results obtained in microgravity are different from those achieved on the ground.

Upon completion of the mission, all hardware will be placed back into its original launch stowage configuration for return on the next available flight back to Earth.

Mission Team Members

Michael López-Alegría

Michael López-Alegría

Larry Connor

Larry Connor

Eytan Stibbe

Eytan Stibbe

Our partners

Our partnersOur partnersOur partners


brain.space is taking part in the Ramon Foundation’s Rakia Mission which is sending 30 groundbreaking experiments to the International Space Station with Israel’s second astronaut, Eytan Stibbe.
The Rakia Mission is a unique opportunity for Israeli entrepreneurs, scientists and researchers to advance innovative ideas by testing their work in space and thereby advancing both Israeli and international research.
EEG headset
EEG headset

Purpose of the Experiments

With long term space exploration, and off-world living within grasp, brain.space has set itself the goal to become the standard for monitoring neurowellness in space.

The Necessity for Neurowellness in Space

While there is data collection being carried out for various physiological measurements, such as heart rate, galvanic skin resistance, and muscle mass, there is currently no high-quality longitudinal data regarding the neural changes in prolonged space missions.
Such information can be vital in assessing day-to-day plastic changes in the brain and predicting how the brain will adapt to long-term space travel.

A First for Neural Science

Previous neural studies in space were carried out using low resolution gel-based EEG systems, which were complex to set up in microgravity and only focused on simple brain activity measurements. Measurements using high-density dry EEG systems were never attempted.
By performing the first ever cognitive experiment using a high-density easy setup EEG system, along with study-proven multi-modal P300 paradigms in space, brain.space will be able to both assess whether there are changes in the astronauts’ cognitive functions, and characterize their dynamics.
With this study, we will be able to demonstrate the feasibility of monitoring cognitive performance and brain activity in a microgravity environment. Among the additional intended outcomes is formulating an assessment for future missions of how well astronauts adapt to the new environments in space.

Intended Goals of the Experiment

The brain.space neurowellness system is a portable electroencephalography (EEG) headset that will observe differences in cognitive performance of a subject in 1-g versus micro-g, when exposed to similar stimuli.
The ability to analyze brain waves can be an essential component in making cognitive diagnosis and monitoring the neuro-health of crews in space.
EEG headset

The technology demonstration of the brain.space neurowellness headset in the International Space Station (ISS) is intended to determine viability for use in future space exploration missions by achieving these goals:

Demonstrate the feasibility of monitoring longitudinal changes in brain activity and cognitive function during space flight using a high-density dry EEG system
Identify and quantify such changes in on-going brain dynamics and activity while performing extensively validated research paradigms.
Provide future long-term space missions with a simple to use, comfortable and accurate device for daily gauging of astronaut competence.

The Experiments

The experiment — spanning 8 days — comprises two daily 15-minute EEG recordings.

  • Real-time flight operations will be conducted from the NASA Glenn Research Center’s (GRC) Telescience Support Center (TSC).
  • Real time video will be routed to the brain.space office in Tel-Aviv for assistance in troubleshooting, or answering crew questions.
  • Data collected in orbit will be transferred to brain.space and Ben-Gurion University researchers after each session for analysis.
EEG headset

Experiment procedure

Experiment procedure

Step 1

Headset setup

Step 2

Resting state (1.5 min with eyes open and 1.5 min with eyes closed.)

Step 3

P300 paradigm.

Experiment 1: Resting State EEG Acquisition

Over the past two decades rs-EEG has emerged as the “gold standard” tool for detecting aberrant brain activity in scenarios ranging from the benign (sleep deprivation) to the pathological (schizophrenia).

EEG headset
EEG headset

Experiment 2: Visual Oddball Task

The purpose of the oddball task is to elicit a response referred to as the ‘P300’, which originates from decision\-making networks. This waveform (peeking around 300-milliseconds after stimulus presentation) is characterized by its amplitude and latency, and has been shown to be effective in detecting abnormal brain dynamics.

Training, Baseline & Post flight Data Collection

Purpose of the Experiments

All astronauts taking part in the study were trained by brain.space and ZIN technologies personnel at the Axiom Space facility in February, 2022. The training procedure included:
  • Familiarization with the hardware interfaces and setup process.
  • Proper donning of the headset.
  • Using brain.space software.
  • Ensuring proper connections and signal quality.
  • Biomedical sterilization procedure.

Baseline Data Collection

  • Conducting the exact experiment as planned in space on ground before the flight, in order to establish a starting point for the astronauts ahead of the mission.
  • Baseline experiments were performed at the SpaceX facility between March 9th to March 11th.

Post flight Data Collection

  • Conducting the exact experiment as planned in space on ground after the flight, in order to demonstrate the after effect, if any, of the mission in microgravity.
EEG headset

The Hardware Payload

The brain.space neurowellness experiment will be performed in front of the Microgravity Science Glovebox (MSG) at MSG LAB1S.
The major components are:
  • The brain.space 115 dry EEG headset.
  • Manual pneumatic control system.
  • System power supply designed for integration with the ISS power grid.
  • Ear clip (reference sensor).
EEG headset
EEG headset
EEG headset